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| Registros recuperados : 55 | |
| 4. |  | BENAVIDES, M. V.; ECHEVARRIA, F. A. M.; SONSTEGARD, T. S.; VAN TESSEL, C. P.; GASBARRE, L. C. Genetic variability of a Bos taurus x Bos indicus cross population and validation of genomic regions influencing nematode resistance. In: SIMPOSIO DE RECURSOS GENETICOS PARA AMERICA LATINA Y EL CARIBE, 5., 2005, Montevideo, Uruguay. Resumenes... Montevideo: INIA :Facultad de Agronomía de la Universidad de la República, 2005. p. 105 SIRGEALC. Resumo 305.| Biblioteca(s): Embrapa Pecuária Sul. |
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| 6. | | SILVA, M. V. G. B.; TASSELL, C. P. V.; SONSTEGARD, T. S.; MATUKUMALLI, L.; SCHROEDER, S.; VANRADEN, P.; WIGGANS, G. Predição do valor genético total de touros da raça Holandesa por meio de mapas densos de marcadores. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA. 45., 2008, Lavras, MG. Anais... Viçosa, MG: Sociedade Brasileira de Zootecnia, 2008.| Biblioteca(s): Embrapa Gado de Leite. |
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| 10. | | PORTO NETO, L. R.; SONSTEGARD, T. S.; LIU, G.; BICKHART, D.; GONDRO, C.; SILVA, M. V. G. B.; UTSUNOMIYA, Y. T.; GARCIA, J. F.; VAN TASSELL, C. P. Genomic divergence of indicine and taurine cattle identified through high-density SNP gebotyping. In: ADSA-ASAS ANNUAL MEETINGS, 2013, Indianápolis, Indiana. Abstracts... Indianápolis: [s.n.], 2013.| Biblioteca(s): Embrapa Gado de Leite. |
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| 11. | | GARCIA, J. F.; CARMO, A. S. DO; UTSUNOMIYA, Y. T.; NEVES, H. H. DE R.; CARVALHEIRO, R.; TASSELL, C. V.; SONSTEGARD, T. S.; SILVA, M. V. G. B. How bioinformatics enables livestock applied sciences in the genomic era. In: BRAZILIAN SYMPOSIUM ON BIOINFORMATICS, 2012, Heidelberg. Proceedings... Porto Alegre: Sociedade Brasileira e Computação, 2012.| Biblioteca(s): Embrapa Gado de Leite. |
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| 12. | | VENERONI, G. B.; MEIRELLES, S. L.; SANTIAGO, A. C.; SONSTEGARD, T. S.; OLIVEIRA, H. N.; YAMAGISHI, M. E. B.; ALENCAR, M. M. de; REGITANO, L. C. de A. Identification of genomic regions associated with backfat thickness in synthetic cattle. In: WORKSHOP DA REDE GENÔMICA ANIMAL, 1., 2009, Fortaleza. Anais... Fortaleza, Rede Genômica Animal, 2009.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 13. | | BENAVIDES, M. V.; SONSTEGARD, T. S.; KEMP, S.; MUGAMBI, J. M.; GIBSON, J. P.; BAKER, R. L.; HANOTTE, O.; MARSHALL, K.; VAN TASSELL, C. Identification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population. Plos One, v. 10, n. 4, e0122797, Apr. 2015.| Biblioteca(s): Embrapa Pecuária Sul; Embrapa Pesca e Aquicultura. |
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| 14. | | ANDREOTE, A. P. D.; ROSÁRIO, M. F. do; LEDUR, M. C.; JORGE, E. C.; SONSTEGARD, T. S.; MATUKUMALLI, L.; COUTINHO, L. L. Identification and characterization of microRNAs expressed in chicken skeletal muscle. Genetics and Molecular Research, v. 6, n. 1, p. 1465-1479, 2014.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 15. | | O'BRIEN, A. M. P.; MÉSZÁROS, G.; UTSUNOMIYA, Y. T.; SONSTEGARD, T. S.; GARCIA, J. F.; TASSEL, C. P. V.; CARVALHEIRO, R.; SILVA, M. V. G. B.; SÖLKNER, J. Linkage disequilibrium levels in Bos indicus and Bos taurus cattle using medium and high density SNP chip data and different minor allele frequency distributions. Livestock Science, v. 166, p. 121-132, 2014.| Biblioteca(s): Embrapa Gado de Leite. |
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| 16. | | O'BRIEN, A. M. P.; UTSUNOMIYA, Y. T.; MÉSZÁROS, G.; BICKHART, D. M.; LIU, G. E.; TASSEL, C. P. V.; SONSTEGARD, T. S.; SILVA, M. V. G. B.; GARCIA, J. F.; SÖLKNER, J. Assessing signatures of selection through variation in linkage disequilibrium between taurine and indicine cattle. Genetics Selection Evolution, v. 46, n. 19, 2014. 14 p.| Biblioteca(s): Embrapa Gado de Leite. |
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| 17. | | MIYATA, M.; GASPARIN, G.; COUTINHO, L. L.; MARTINEZ. M. L.; MACHADO, M. A.; SILVA, M. V. G. B.; CAMPOS, A. L.; SONSTEGARD, T. S.; REGITANO, L. C. de A. Caracterização genética de uma população experimental F2 usando marcadores moleculares no cromossomo 14 ( BTA 14) de bovinos. In: CONGRESSO BRASILEIRO DE GENÉTICA , 51., 2005, Águas de Lindóia. Lindóia: SBG, 2005. p. 364| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 18. | | SILVA, M. V. G. B.; SANTOS, D. J. A. dos; BOISON, S. A.; UTSUNOMIYA, A. T. H.; CARMO, A. S.; SONSTEGARD, T. S.; COLE, J. B.; TASSELL, C. P. V. The development of genomics applied to dairy breeding. Livestock Science, v. 166, p. 66-75, 2014.| Biblioteca(s): Embrapa Gado de Leite. |
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| 19. | | REIS, D. R. de L.; PEREIRA, H. P.; EGITO, A. A. do; TORRES JUNIOR, R. A. de A.; KIM, E. S.; SONSTEGARD, T. S.; MARTINS, M. F.; PANETTO, J. C. do C.; SILVA, M. V. G. B.; MACHADO, M. A. Development of tetra-primer ARMS-PCR protocol to genotype the prolactin receptor SNP 39136666 and assessment of this SNP in Brazilian locally adapted cattle breeds. Arquivo Brasileiro e Medicina Veterinária e Zootecnia, v. 73, p. 534-538, 2021. Communication.| Biblioteca(s): Embrapa Gado de Leite. |
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| 20. | | SILVA, M. V. G. B.; VERNEQUE, R. da S.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; GUIMARAES, M. F. M.; ARBEX, W. A.; GUEDES, E.; VAN TASSELL, C. P.; SONSTEGARD, T. S. Genome-wide association analysis to identify loci for milk yield in Gyr breed. In: INTERNATIONAL CONFERENCE ON ANIMAL GENETICS, 32., 2010, Edinburgh. Proceedings... Edinburgh: International Society for Animal Genetics, 2010.| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 55 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
28/11/2014 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
O'BRIEN, A. M. P.; MÉSZÁROS, G.; UTSUNOMIYA, Y. T.; SONSTEGARD, T. S.; GARCIA, J. F.; TASSEL, C. P. V.; CARVALHEIRO, R.; SILVA, M. V. G. B.; SÖLKNER, J. |
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Afiliação: |
ANA M. PÉREZ O'BRIEN, University of Natural Resources and Life Sciences, Vienna; GÁBOR MÉSZÁROS, University of Natural Resources and Life Sciences, Vienna; YURI T. UTSUNOMIYA, UNESP; TAD S. SONSTEGARD, ARS-USDA, USA; JOSÉ F. GARCIA, UNESP; CURTIS P. VAN TASSEL, ARS-USDA, USA; ROBERTO CARVALHEIRO, GenSys Consultores Associados; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; JOHANN SÖLKNER, University of Natural Resources and Life Sciences, Vienna. |
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Título: |
Linkage disequilibrium levels in Bos indicus and Bos taurus cattle using medium and high density SNP chip data and different minor allele frequency distributions. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Livestock Science, v. 166, p. 121-132, 2014. |
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Idioma: |
Inglês |
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Conteúdo: |
Linkage disequilibrium (LD), the observed correlation between alleles at different loci in the genome, is a determinant parameter in many applications of molecular genetics. With the wider use of genomic technologies in animal breeding and animal genetics, it is worthwhile revising and improving the current knowledge and understanding of cattle LD. This study analyzes levels of LD assessed through the r2 measurement in seven breeds of cattle from both indicine (Bos indicus) and taurine (Bos taurus) (sub)species, genotyped with a high density panel (HD) of over 777,000 single nucleotide polymorphism (SNP) markers. Average levels of LD were assessed for inter-marker distances from 0 kb up to 10 Mb. Two more SNP panels were built in silico from the original genotypes to represent a lower density SNP chip including approximately 50,000 SNPs (50K) and a panel of 249,000 SNPs chosen to comply with specific minor allele frequency (MAF) distributions. The results show higher levels of LD than previously reported, especially at short inter-marker distances of less than 20 kb, assessed through the use of the higher density panel. Negligible impact of MAF changes in the estimation of r2 was observed, supporting the use of the HD panel for LD-based methodologies even when ascertainment bias in the choice of SNPs is suspected. The 50K SNP panel indicated lower levels of LD in the first 100 kb and highly unreliable LD estimates for distances shorter than 50 kb. Overall, lower levels of LD were observed for all indicine breeds as compared to taurine breeds, with larger differences assessed in the first 100 kb, suggesting the need for use of higher SNP densities in this (sub)species when applying LD-dependent methods, as compared to most taurine breeds. MenosLinkage disequilibrium (LD), the observed correlation between alleles at different loci in the genome, is a determinant parameter in many applications of molecular genetics. With the wider use of genomic technologies in animal breeding and animal genetics, it is worthwhile revising and improving the current knowledge and understanding of cattle LD. This study analyzes levels of LD assessed through the r2 measurement in seven breeds of cattle from both indicine (Bos indicus) and taurine (Bos taurus) (sub)species, genotyped with a high density panel (HD) of over 777,000 single nucleotide polymorphism (SNP) markers. Average levels of LD were assessed for inter-marker distances from 0 kb up to 10 Mb. Two more SNP panels were built in silico from the original genotypes to represent a lower density SNP chip including approximately 50,000 SNPs (50K) and a panel of 249,000 SNPs chosen to comply with specific minor allele frequency (MAF) distributions. The results show higher levels of LD than previously reported, especially at short inter-marker distances of less than 20 kb, assessed through the use of the higher density panel. Negligible impact of MAF changes in the estimation of r2 was observed, supporting the use of the HD panel for LD-based methodologies even when ascertainment bias in the choice of SNPs is suspected. The 50K SNP panel indicated lower levels of LD in the first 100 kb and highly unreliable LD estimates for distances shorter than 50 kb. Overall, lower levels of LD... Mostrar Tudo |
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Palavras-Chave: |
Indicine; Minor allele frequency. |
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Thesaurus NAL: |
cattle; linkage disequilibrium; taurine. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02632naa a2200277 a 4500
001 2001105
005 2024-02-05
008 2014 bl uuuu u00u1 u #d
100 1 $aO'BRIEN, A. M. P.
245 $aLinkage disequilibrium levels in Bos indicus and Bos taurus cattle using medium and high density SNP chip data and different minor allele frequency distributions.$h[electronic resource]
260 $c2014
520 $aLinkage disequilibrium (LD), the observed correlation between alleles at different loci in the genome, is a determinant parameter in many applications of molecular genetics. With the wider use of genomic technologies in animal breeding and animal genetics, it is worthwhile revising and improving the current knowledge and understanding of cattle LD. This study analyzes levels of LD assessed through the r2 measurement in seven breeds of cattle from both indicine (Bos indicus) and taurine (Bos taurus) (sub)species, genotyped with a high density panel (HD) of over 777,000 single nucleotide polymorphism (SNP) markers. Average levels of LD were assessed for inter-marker distances from 0 kb up to 10 Mb. Two more SNP panels were built in silico from the original genotypes to represent a lower density SNP chip including approximately 50,000 SNPs (50K) and a panel of 249,000 SNPs chosen to comply with specific minor allele frequency (MAF) distributions. The results show higher levels of LD than previously reported, especially at short inter-marker distances of less than 20 kb, assessed through the use of the higher density panel. Negligible impact of MAF changes in the estimation of r2 was observed, supporting the use of the HD panel for LD-based methodologies even when ascertainment bias in the choice of SNPs is suspected. The 50K SNP panel indicated lower levels of LD in the first 100 kb and highly unreliable LD estimates for distances shorter than 50 kb. Overall, lower levels of LD were observed for all indicine breeds as compared to taurine breeds, with larger differences assessed in the first 100 kb, suggesting the need for use of higher SNP densities in this (sub)species when applying LD-dependent methods, as compared to most taurine breeds.
650 $acattle
650 $alinkage disequilibrium
650 $ataurine
653 $aIndicine
653 $aMinor allele frequency
700 1 $aMÉSZÁROS, G.
700 1 $aUTSUNOMIYA, Y. T.
700 1 $aSONSTEGARD, T. S.
700 1 $aGARCIA, J. F.
700 1 $aTASSEL, C. P. V.
700 1 $aCARVALHEIRO, R.
700 1 $aSILVA, M. V. G. B.
700 1 $aSÖLKNER, J.
773 $tLivestock Science$gv. 166, p. 121-132, 2014.
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